Cosmetic Grade L-Proline(CAS 147-85-3)
Product Name: L-Proline
Abbreviation: Pro
Chemical Name: L-Pyrrolidine-2-Carboxylic Acid
CAS No.: 147-85-3
Grade: Cosmetic Grade (Skin Care Special)
Purity: ≥99.0%
Appearance: White Orthorhombic Crystal or Crystalline Powder, Odorless, Slightly Sweet and Neutral Taste
Molecular Weight: 115.13
Molecular Formula: C₅H₉NO₂
MOQ (Minimum Order Quantity): 1KG
Solubility: Easily soluble in water, soluble in ethanol, insoluble in ether and other organic solvents, fast dissolution speed, clear and transparent aqueous solution without impurities and precipitation, stable formula compatibility
Specific Rotation: -84.0° ~ -87.0°
pH Value (1% Aqueous Solution): 5.5 - 7.0
Key Characteristics: Unique cyclic amino acid, core collagen synthetic precursor, powerful anti-wrinkle and firming effect, excellent water-locking moisturizing performance, promote skin tissue repair, mild antioxidant, ultra-safe and skin-friendly, widely compatible with cosmetic formulas
Storage Condition: Sealed, dry, cool and dark ventilated environment, avoid high temperature, strong light and humid air, prevent moisture absorption, discoloration and agglomeration, keep dry and clean for long-term storage
Shelf Life: 24 Months
Application: Widely used in anti-wrinkle firming skin care products, collagen regenerating cosmetics, dry skin deep moisturizing series, skin tissue repair formulas and high-end anti-aging functional skin care products
L-Proline, Cosmetic Grade L-Proline, Collagen Precursor Amino Acid, Anti-Wrinkle, Skin Firming, Deep Moisturizing, Anti-Aging, Skin Elasticity Repair, Mild Cosmetic Raw Material
Cosmetic Grade L-Proline(CAS 147-85-3)
Cosmetic-grade L-Proline is a high-purity cyclic structured amino acid refined by advanced biological fermentation and purification technology, serving as one of the most core precursor substances for human skin collagen and elastin synthesis. Different from linear amino acids, its unique pyrrolidine cyclic structure endows it with superior molecular stability and skin affinity, which can directly participate in the proliferation and repair of skin fibroblasts, effectively promote collagen and elastic fiber regeneration, fundamentally improve skin relaxation, sagging, fine lines and dry wrinkles caused by collagen loss.
L-Proline owns excellent natural water-locking and moisturizing activity, which can bind skin water molecules to form a dense water-retaining protective layer, relieve long-term dryness, rough texture and tight peeling of dry skin, and maintain long-lasting skin plumpness and moisture.
Meanwhile, it has mild antioxidant and anti-aging effects, which can scavenge skin free radicals, reduce oxidative damage, delay skin tissue aging, and improve dull and tired skin tone. With ultra-mild neutral skin-friendly properties, zero irritation and low sensitization, it will not cause burden or irritation to fragile skin.
It can be perfectly compounded with various anti-aging peptides, moisturizing factors and repair ingredients to synergistically enhance the firming and anti-wrinkle efficacy of finished products. It is an indispensable core functional raw material for high-end anti-aging, firming and moisturizing skin care products.



Key Benefits
• Core Collagen Precursor, Anti-Wrinkle & Firming: Unique cyclic structure efficiently promotes collagen and elastin synthesis, fades dry fine lines and texture wrinkles, tightens loose skin, and restores skin firmness.
• Superior Water-Locking, Long-Lasting Moisturizing: Stably bind skin water molecules, form a breathable moisturizing film, relieve dry tightness and rough peeling, and maintain 24-hour plump and moist skin.
• Promote Skin Tissue Repair: Activate skin fibroblast activity, accelerate damaged skin tissue repair, improve fragile skin texture, and enhance skin self-repair ability.
• Mild Anti-Oxidation, Delay Skin Aging: Scavenge excess skin free radicals, reduce oxidative aging damage, improve dull and yellowish skin tone, and keep skin youthful and translucent.
• Ultra-Mild & Low-Sensitivity Safety: Natural cyclic amino acid, neutral skin-friendly pH, zero irritation, safe for sensitive skin, dry skin and long-term daily skin care.
• High Formula Compatibility & Stability: Excellent formula tolerance, not easy to deteriorate or inactivate, freely compoundable with peptides, vitamins and plant extracts to synergistically amplify skin care efficacy.
Applications
• Anti-Wrinkle & Firming Anti-Aging Series: Core functional raw materials for anti-aging essence, firming lotion, anti-wrinkle cream and lifting mask, targeting fine lines, sagging and loose skin texture.
• Dry Skin Deep Moisturizing Products: Applied in high moisturizing toner, long-lasting hydrating cream and dry skin care formulas to improve persistent dryness, rough peeling and tight skin.
• Skin Tissue Repair & Maintenance Cosmetics: Added in barrier repair lotion, fragile skin conditioning products and post-damage repair formulas to enhance skin repair power.
• Collagen Regenerating Skin Care: Suitable for collagen replenishing and anti-aging skin care series, assist collagen regeneration, improve skin elasticity and plumpness.
• High-End Mild Functional Compound Cosmetics: Widely used in high-end anti-aging, moisturizing and repairing compound formulas, suitable for medical mild skin care and mature skin dedicated maintenance products.
Certificate Of Analysis (COA)
Test Item | Standard Specification | Test Result |
Product Name | L-Proline | Compliant |
CAS No. | 147-85-3 | Compliant |
Appearance | White Crystalline Powder, Odorless | Compliant |
Purity | ≥99.0% | 99.73% |
Specific Rotation | -84.0° ~ -87.0° | -85.6° |
Loss on Drying | ≤0.2% | 0.04% |
Residue on Ignition | ≤0.1% | 0.02% |
Heavy Metal (Pb) | ≤10ppm | Qualified |
Arsenic (As) | ≤2ppm | Qualified |
pH Value (1% Solution) | 5.5 - 7.0 | 6.2 |
Conclusion | Conforms to cosmetic grade quality standard | Qualified |
Frequently Asked Questions (FAQ)
• Q1: What is the MOQ of cosmetic grade L-Proline?
A1: The standard MOQ is 1KG, and sample orders are supported for quality testing.
• Q2: What certification documents can be provided?
A2: Complete COA, MSDS and full set of global customs clearance documents are available.
• Q3: What is the recommended dosage in cosmetic formulas?
A3: Conventional addition ratio is 0.3%-3.0%, with stable anti-wrinkle, firming and moisturizing effects, mild and non-burden on skin.
• Q4: What is the core advantage of L-Proline?
A4: It is a unique cyclic amino acid and core collagen precursor, integrating anti-wrinkle firming, deep moisturizing and skin repair, with more stable efficacy than ordinary linear amino acids.
• Q5: Is L-Proline suitable for mature skin care formulas?
A5: Yes, it is specially designed for mature skin anti-aging maintenance, effectively improves collagen loss problems, fades fine lines and tightens skin, and is safe for long-term use.
• Q6: Do you support stable large-batch supply all year round?
A6: Sufficient factory capacity ensures continuous and stable bulk supply throughout the year.
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