Hexamidine Diisethionate High Purity Anti-acne Anti-dandruff Cosmetic Raw Material
Product Name: Hexamidine Diisethionate
Chemical Name: Hexamidine Di(2-hydroxyethanesulfonate)
INCI Name: Hexamidine Diisethionate
CAS Number: 659-40-5
EINECS Number: 617-849-3
Molecular Formula: C24H38N4O10S2
Molecular Weight: 606.72
Purity: ≥99.0% (HPLC)
Appearance: White Crystalline Powder, Slight Odor, Uniform Texture
Solubility: Easily soluble in water and propylene glycol, soluble in ethanol, insoluble in cosmetic greases
Effective pH Range: 4.0-8.0, stable in conventional cosmetic formula environment
Grade: Cosmetic Grade, High-efficiency Bacteriostatic Grade, Global Regulatory Compliant
MOQ: 100g / 1KG
Shelf Life: 24 months (sealed, light-proof, cool and dry storage below 25℃)
Product Features: High-efficiency broad-spectrum bacteriostasis, mild and non-irritating, no drug resistance, stable high-temperature processing
Hexamidine Diisethionate, Cosmetic Antibacterial Agent, Anti-acne Skin Care Raw Material, Anti-dandruff Scalp Care Ingredient, Water-soluble Preservative, Mild Skin Purifying Additive, Global Compliant Cosmetic Biocide
Hexamidine Diisethionate-CAS 659-40-5
Hexamidine Diisethionate is a high-purity water-soluble cosmetic bacteriostatic functional raw material, belonging to amidine derivative compounds.
With 99% high purity, it has targeted and efficient inhibitory effect on common harmful microorganisms in skin and scalp, with outstanding anti-acne and anti-dandruff effects.
Different from traditional irritating antibacterial raw materials, it features mild properties, no skin irritation, no sensitization and no microbial resistance.
It maintains stable activity in conventional cosmetic production processes, does not affect product color and skin feel, and complies with global cosmetic safety regulations.
It is a core mild functional additive for oil-control anti-acne skin care and healthy scalp maintenance formulas.



Key Benefits
• Targeted Anti-acne & Purifying: Effectively inhibits acne-related microorganisms, improves oily acne-prone skin, reduces closed comedones and inflammatory skin problems, and purifies skin microenvironment.
• Efficient Anti-dandruff & Scalp Care: Suppresses scalp harmful bacteria and fungal reproduction, relieves scalp itching and flaking, controls scalp oil secretion, and maintains fresh scalp state.
• Mild & Low Irritation: Pure high-purity raw material, mild formula, non-irritating to skin and scalp, friendly to sensitive acne-prone skin.
• Stable & No Resistance: Long-term use will not cause microbial drug resistance, stable bacteriostatic activity in wide pH range and high-temperature processing.
• Excellent Formula Compatibility: Water-soluble system, compatible with most cosmetic raw materials, does not discolor or precipitate, does not damage product sensory experience.
• Global Compliance & Safe: Approved for use in China, EU, FDA and other global cosmetic regulations, safe for long-term formula addition.
Applications
• Anti-acne Skin Care Series: Anti-acne essence, purifying toner, oil-control acne cream, closed-comedone repair skin care products.
• Scalp Care Series: Anti-dandruff shampoo, oil-control scalp lotion, itchy scalp soothing maintenance products.
• Mild Purifying Series: Pore cleansing products, oily skin balancing formulas, daily skin purifying maintenance cosmetics.
• Sensitive Oil Skin Series: Mild oil-control soothing products, sensitive acne-prone skin maintenance formulas.
• Functional Cleansing Series: Anti-acne facial cleanser, scalp cleansing foam, mild bacteriostatic cleaning products.
• Water-soluble Functional Formulas: Water-based essence, moisturizing lotion, transparent refreshing skin care systems.
Certificate Of Analysis (COA)
Test Item | Standard Specification | Test Result |
Product Name | Hexamidine Diisethionate | Compliant |
Appearance (25℃) | White Crystalline Powder | White Uniform Crystalline Powder |
Purity (HPLC) | ≥99.0% | 99.4% |
Loss on Drying | ≤0.5% | 0.22% |
Ash Content | ≤0.1% | 0.07% |
pH Value (1% Water Solution) | 5.0-7.0 | 6.1 |
Heavy Metal (Pb) | ≤1ppm | <0.5ppm |
Arsenic (As) | ≤0.2ppm | Qualified |
Microorganism | Total Plate Count ≤100CFU/g | Qualified |
Conclusion | Meets global cosmetic grade raw material standards | Qualified |
Frequently Asked Questions (FAQ)
• Q1: What is the core advantage of this raw material?
A1: 99% high purity, mild and non-irritating, targeted anti-acne and anti-dandruff, no microbial resistance, global compliant.
• Q2: What is the safe addition dosage for mass production?
A2: Conventional skin care products 0.05%-0.2%, anti-acne formulas 0.2%-0.5%, shampoo products 0.1%-0.3%.
• Q3: What solvent is suitable for dissolution?
A3: Pre-dissolve with water or propylene glycol at normal temperature, easy to disperse without precipitation in water-based systems.
• Q4: Can it be compounded with other antibacterial ingredients?
A4: Yes, it can compound with mild preservatives and plant extracts to synergize purifying and bacteriostatic effects.
• Q5: How to store bulk stock to keep activity stable?
A5: Sealed, light-proof and low-temperature dry storage, avoid high temperature and humid environment.
• Q6: Do you support sample test and bulk customized supply?
A6: Support small batch trial samples and bulk supply, provide complete qualification and technical guidance.
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