Polylysine Hydrochloride Natural Biological Preservative
Product Name: Polylysine Hydrochloride
Common Name: Polylysine Hydrochloride
INCI Name: Polylysine Hydrochloride
CAS Number: 25104-18-1
Source: Microbial fermentation from Streptomyces diastatochromogenes
Molecular Formula: (C₆H₁₂N₂O)n·HCl
Appearance: White to off-white crystalline powder, odorless, non-hygroscopic
Purity: ≥99.0% (HPLC), Food & Cosmetic Dual Grade
Solubility: Freely soluble in water, soluble in propylene glycol, insoluble in oil phase and organic solvents
Effective pH Range: 2.0–9.0, ultra-wide pH stability
Heat Resistance: Stable bacteriostatic activity up to 120℃, suitable for high-temperature sterilization processes
Max Legal Dosage (Cosmetic): 0.1% globally compliant
Grade: Food Grade / Cosmetic Grade, Clean Beauty Certified, Zero Irritation Grade
MOQ: 100g / 1KG / 25KG Drum
Shelf Life: 24 months (sealed, light-proof, cool and dry storage below 25℃)
Key Features: Natural fermentation source, food-grade safety, broad-spectrum bacteriostasis, high temperature resistant, no drug resistance, fully biodegradable
Polylysine Hydrochloride, Polylysine Hydrochloride, Natural Biological Preservative, Food Grade Cosmetic Raw Material, Non-irritating Preservative, High Temperature Resistant, Wide pH Bacteriostatic, Clean Beauty Preservative, Baby Safe Cosmetic Additive
Polylysine Hydrochloride-CAS 25104-18-1
Polylysine Hydrochloride is a high-safe natural biological preservative fermented and purified by microbial technology.
Different from traditional chemical preservatives, it belongs to cationic polypeptide active substance with food-grade safety attributes.
It efficiently inhibits gram-positive bacteria, gram-negative bacteria, molds and yeasts, solving product deterioration, mildew and odor problems from the source.
With ultra-wide pH adaptability and excellent thermal stability, it maintains stable efficacy in acidic, neutral and weak alkaline systems, and withstands conventional cosmetic high-temperature production processes.
The raw material is non-irritating, non-sensitizing, non-toxic and fully biodegradable, leaving no chemical residues.
It is the core preferred preservative for high-end clean beauty, maternal and infant care, sensitive skin and zero-add mild cosmetic formulas, compliant with China, EU and global cosmetic regulations.



Key Benefits
• Food-grade Safety & Zero Irritation: Natural microbial fermentation source, food-additive grade safety standard, non-toxic, non-sensitizing, no skin and mucosal irritation, specially suitable for pregnant women, infants and sensitive fragile skin.
• Full Broad-spectrum Bacteriostasis: Effectively suppresses bacteria, molds and yeasts, covers all common spoilage microorganisms in cosmetics, comprehensively guarantees formula long-term stability.
• Ultra-wide Environmental Adaptability: Stable and effective in pH 2.0–9.0 full range, resistant to high temperature processing, no activity loss in high-temperature sterilization and emulsification processes.
• No Drug Resistance & Green Degradation: Long-term use does not produce microbial drug resistance, fully biodegradable, green and environmentally friendly, no residual pollution, meets clean beauty green standards.
• Excellent Formula Compatibility: Excellent water solubility, compatible with all conventional cosmetic raw materials and surfactant systems, no precipitation, discoloration or peculiar smell, does not affect product skin feel and transparency.
• Low Dosage & High Stability: Low effective concentration, stable long-term efficacy, can be used alone or compounded to reduce overall preservative dosage and optimize formula safety.
Applications
• Sensitive Skin Care Series: Soothing toner, moisturizing lotion, repair essence, sensitive skin barrier care products, zero-irritation daily skin care.
• Maternal & Infant Care Series: Pregnant women skin care, baby shampoo and body wash, infant moisturizing cream, mild nursing formulas.
• Clean & Zero-add Beauty Series: Pure plant formulas, zero chemical preservative addition schemes, green mild skin care products.
• Water-based High-moisture Products: Hydrating spray, moisturizing water, water-soluble essence, transparent fresh skin care with high water content.
• Food-contact Daily Chemicals: Hand sanitizer, fruit and vegetable cleaning lotion, skin care and cleaning products that can contact food.
• Mild Functional Cosmetics: Acne-soothing skin care, oil-water balancing products, mild bacteriostatic and anti-inflammatory daily chemical formulas.
Certificate Of Analysis (COA)
Test Item | Standard Specification | Test Result |
Product Name | ε-Polylysine Hydrochloride | Compliant |
Appearance | White to Off-white Crystalline Powder | White Uniform Powder |
Purity (HPLC) | ≥99.0% | 99.6% |
Loss on Drying | ≤5.0% | 2.08% |
Residue on Ignition | ≤1.0% | 0.40% |
pH (1% Aqueous Solution) | 5.0–7.0 | 6.2 |
Heavy Metal (Pb) | ≤1ppm | <0.5ppm |
Arsenic (As) | ≤0.2ppm | Qualified |
Total Microorganism | ≤100CFU/g | Qualified |
Conclusion | Meets food & cosmetic grade standards | Qualified |
Frequently Asked Questions (FAQ)
• Q1: What makes Polylysine Hydrochloride different from traditional preservatives?
A1: It is a natural fermented polypeptide preservative with food-grade safety, zero irritation, high temperature resistance and wide pH efficacy. No chemical residues and no drug resistance, ideal for clean beauty and maternal-infant formulas.
• Q2: What is the compliant dosage for cosmetics?
A2: Global maximum legal limit 0.1%. Recommended dosage: conventional skin care 0.02%–0.05%, high-water formulas 0.05%–0.08%, maternal & infant products 0.02%–0.04%.
• Q3: How to dissolve and add correctly?
A3: Water-phase addition, freely soluble in normal-temperature water, stir evenly without heating. Simple operation, no precipitation or stratification.
• Q4: What ingredients are suitable for compounding?
A4: Synergizes well with phenoxyethanol, ethylhexylglycerin, plant preservatives and polyols, enhances antiseptic efficiency and reduces single-preservative dosage.
• Q5: Is it safe for sensitive skin and babies?
A5: Food-grade non-toxic raw material, non-irritating and non-sensitizing, officially approved for sensitive skin and infant mild care products.
• Q6: Does high temperature and pH fluctuation affect efficacy?
A6: Stable at 120℃ high temperature and pH 2.0–9.0 range, no efficacy attenuation during cosmetic emulsification and sterilization process.
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