Potassium 4-Methoxysalicylate(4MSK)-CAS 152312-71-5
Product Name: Potassium 4-Methoxysalicylate
Abbreviation: 4MSK
INCI Name: Potassium Methoxysalicylate
CAS No.: 152312-71-5
Grade: Cosmetic Grade (High-End Brightening & Skin Repair Special)
Purity: ≥99.0%
Appearance: White Fine Crystalline Powder, Odorless
Molecular Formula: C₈H₇KO₄
Molecular Weight: 206.24
MOQ (Minimum Order Quantity): 1KG
Solubility: Extremely soluble in water, soluble in glycerin, propylene glycol and other polar aqueous solvents, clear and transparent aqueous solution, no precipitation, insoluble in non-polar oil-phase solvents, excellent water-phase formula compatibility
Core Efficacy: Inhibit melanin synthesis, accelerate melanin metabolism, regulate keratin renewal, repair damaged skin barrier, resist oxidation and light damage, even skin tone and fade pigmentation
Key Characteristics: Japan-approved quasi-drug whitening ingredient, dual mechanism of inhibiting & metabolizing melanin, mild exfoliation without irritation, barrier repair capability, stable water solubility, high safety, compatible with mainstream whitening systems
Storage Condition: Sealed, dry, cool and ventilated environment, avoid high temperature, strong light and humid storage conditions to prevent moisture agglomeration and efficacy attenuation, keep tightly sealed after opening
Shelf Life: 24 Months
Application: Widely used in high-end whitening essence, spot fading serum, brightening toner, anti-photoaging skin care products, barrier repair lotion, facial mask and daily whitening and skin rejuvenation formulas
Potassium 4-Methoxysalicylate, 4MSK, Brightening Agent, Spot Fading, Melanin Inhibition, Keratin Regulation, Anti-Oxidation, Skin Barrier Repair, Water-Soluble Skin Care Raw Material, Cosmetic Grade
Potassium 4-Methoxysalicylate(4MSK)-CAS 152312-71-5
Cosmetic-grade Potassium 4-Methoxysalicylate (4MSK) is a high-efficiency water-soluble whitening and skin-repairing derivative of salicylic acid, officially approved as a quasi-drug whitening active ingredient in Japan, and is a core star material in the global high-end brightening skin care field. Different from single-effect whitening raw materials, 4MSK adopts a dual-efficiency whitening mechanism of "inhibiting melanin + accelerating metabolism".
It can effectively block the transmission of melanin synthesis signals from the source, inhibit the activity of tyrosinase, and prevent excessive pigment production. At the same time, it mildly acts on the skin keratin layer, accelerate the shedding and metabolism of aged keratin and accumulated melanin, quickly fade dullness, yellowish tint and pigmentation, and achieve uniform and translucent skin tone.
Compared with traditional salicylic acid, 4MSK has higher water solubility and milder irritation, with unique skin barrier repair and anti-oxidation functions. It can effectively relieve skin damage caused by ultraviolet radiation, reduce light-induced aging and darkening, and solve common skin problems such as uneven skin tone, dullness and post-sun tanning. With stable water-phase performance, no discoloration or inactivation, wide formula compatibility and high safety, it is an essential multifunctional raw material for developing high-efficiency, mild and long-term whitening skin care products.
Key Benefits
• Dual Whitening Mechanism, Significant Brightening Effect: Double efficacy of inhibiting melanin synthesis and accelerating pigment metabolism, fundamentally improve dull yellow and uneven skin tone, fade spots and post-sun pigmentation with remarkable brightening effect.
• Mild & Low-Irritation Exfoliation: Optimized salicylic acid derivative structure, weaker irritation than traditional salicylic acid, mild keratin regulation without damaging skin barrier, suitable for long-term daily brightening care.
• Anti-Photoaging & Anti-Oxidation: Effectively resist UV-induced light damage, scavenge free radicals, reduce light-induced darkening and aging, cooperate with sunscreen systems to improve comprehensive light protection effect.
• Skin Barrier Repair Capability: Regulate skin keratin metabolism rhythm, repair damaged superficial barrier caused by sun exposure and dryness, improve skin smoothness and delicate degree.
• Excellent Water-Soluble Stability: Super high water solubility, clear solution without precipitation, stable performance in wide pH range, no discoloration or efficacy attenuation, easy for formula production and processing.
• High Safety & Global Compliance: Approved by Japanese quasi-drug whitening standard, mild and non-sensitizing, low skin irritation, compliant with Chinese, European and American cosmetic regulations, suitable for all skin types including sensitive skin.
Applications
• High-End Whitening & Brightening Essence: Core brightening raw material for high-efficiency whitening essence, fade dull yellow and pigmentation, improve skin translucency, and create uniform and bright skin tone.
• Spot Fading & Post-Sun Repair Products: Applied in spot fading serum and after-sun repair lotion, targetedly improve sun tanning and post-inflammatory pigmentation, inhibit melanin recurrence.
• Brightening Toner & Lotion: Added in daily brightening skin care water and milk formulas, mild in texture, long-term use to improve overall skin dullness and maintain translucent skin state.
• Anti-Photoaging Composite Skin Care Products: Compounded with sunscreen agents and antioxidant ingredients to build light damage defense system, resist photoaging and fix light-induced darkening problems.
• Barrier Repair & Sensitive Skin Brightening Products: Suitable for mild brightening formulas for sensitive skin, balance exfoliation and barrier protection, achieve brightening without irritation.
Certificate Of Analysis (COA)
Test Item | Standard Specification | Test Result |
Product Name | Potassium 4-Methoxysalicylate (4MSK) | Compliant |
CAS No. | 152312-71-5 | Compliant |
Appearance | White Fine Crystalline Powder, Odorless | Compliant |
Purity | ≥99.0% | 99.62% |
Water Solubility | Easily soluble in water, clear solution | Qualified |
Loss on Drying | ≤0.5% | 0.12% |
pH Value (1% Aqueous Solution) | 6.5-8.5 | 7.2 |
Heavy Metal (Pb) | ≤10ppm | Qualified |
Arsenic (As) | ≤2ppm | Qualified |
Residue on Ignition | ≤0.1% | 0.04% |
Conclusion | Conforms to cosmetic grade quality standard | Qualified |
Frequently Asked Questions (FAQ)
• Q1: What is the MOQ of cosmetic grade 4MSK?
A1: The standard MOQ is 1KG, and sample orders are supported for formula testing and stability trial production.
• Q2: What certification documents can be provided?
A2: Complete COA, MSDS and full set of global customs clearance documents are available to support export declaration and cosmetic filing.
• Q3: What is the recommended dosage in skin care formulas?
A3: Conventional addition ratio is 1.0%-3.0% for daily brightening skin care, 3.0%-5.0% for high-efficiency whitening essence and spot fading products, adjustable according to efficacy demands.
• Q4: What is the core advantage of 4MSK compared with ordinary whitening ingredients?
A4: 4MSK has dual whitening mechanism of inhibition and metabolism, plus barrier repair and anti-photoaging functions, milder than salicylic acid, higher safety, and suitable for long-term systemic whitening.
• Q5: What ingredients is 4MSK suitable for compounding?
A5: It can be perfectly compounded with nicotinamide, VC derivatives, tranexamic acid and sunscreen agents to build multi-dimensional whitening and anti-light-aging system, significantly improve product efficacy.
• Q6: Do you support stable large-batch supply all year round?
A6: Sufficient factory production capacity ensures continuous, stable and large-volume supply throughout the year to support long-term cooperative orders and customized formula demands.
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